Steroid therapy and adrenal insufficiency

Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes. [46]

18 trials (1179 participants) were included in this updated review . The injection sites varied from epidural sites and facet joints (. intra-articular injections, peri-articular injections and nerve blocks) to local sites (. tender- and trigger points). The drugs that were studied consisted of corticosteroids, local anesthetics and a variety of other drugs. The methodological quality of the trials was limited with 10 out of 18 trials rated as having a high methodological quality. Statistical pooling was not possible due to clinical heterogeneity in the trials. Overall, the results indicated that there is no strong evidence for or against the use of any type of injection therapy .

It must be noted possible side-effects such as Gynecomastia , water retention, high blood pressure and high cholesterol are all a possibility with this cycle as both Testosterone and Dianabol aromatize and cause a buildup in estrogen . If you’re nipples begin to get sore while on cycle you might try supplementing with 10mg of Nolvadex per day. If this does not work you are going to need an Aromatase Inhibitor such as Arimidex or Letrozole ; every other day of either should suffice. Further, if you keep your diet clean you will largely protect from water retention; some will occur if you are really trying to bulk but limit your excess calories only to what you absolutely need and avoid overeating carbohydrates. Further, keeping your diet clean is also good for your blood pressure and cholesterol; moreover, consuming plenty of Omega-3 Fatty Acids can greatly serve you here.

Steroid therapy and adrenal insufficiency

steroid therapy and adrenal insufficiency

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