In a 52-week double-blind, placebo-controlled safety trial that included 663 adults and adolescent patients (441 treated with ciclesonide: 227 males and 436 females) with perennial allergic rhinitis, the adverse reaction profile over the treatment period was similar to the adverse event profile in trials of shorter duration. �Adverse reactions, irrespective of drug relationship, that occurred with an incidence of 3% or greater and more frequently with OMNARIS Nasal Spray 200 mcg than with placebo were epistaxis, pharyngolaryngeal pain, sinusitis , headache, nasal discomfort, cough, bronchitis , influenza , back pain, and urinary tract infection . No patient experienced a nasal septal perforation or nasal ulcer during this long-term trial of OMNARIS Nasal Spray.
It may take up to 4 weeks for the ears to start feeling normal. One must also try to pop the ears immediately after nasal spray use and every hour while awake throughout this period of time. When one tries to pop the ears, try to blow out your nose with your nose pinched shut with your fingers. Popping the ears in this manner, esp after nasal spray use helps to squeeze some of the medication into the eustachian tube. Do not exceed the pressure one uses as if you have mild constipation. Swallowing or yawning does not work as well in this situation.