In most cases, inflammation is a wondrous healing mechanism. However, during eczema flare-ups as well as other inflammatory disorders, the immune system attacks otherwise healthy tissues in error. Several proteins and enzymes have been identified as pro-inflammatory, but the enzyme COX-2 specifically is found at elevated levels during inflammation. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and aspirin were developed with the purpose of targeting and inhibiting the production of COX-2, thereby reducing pain, swelling, and fever.
It is characterized by serious local or disseminated, umbilicated, vesicular, crusting skin rashes in the face, neck, chest, abdomen, upper limbs and hands, caused by widespread infection of the skin in people with previous diagnosed skin conditions such as eczema or atopic dermatitis , even if the conditions are not active at the time. Other signs and symptoms include fever and facial and supraglottic edema . The condition may be fatal if severe and left untreated. Survivors are likely to have some scarring (pockmarks).