Neurosteroids depression

In the mid 1980s, the neuroactive steroids 3α,5α-tetrahydroprogesterone or allopregnanolone (3α,5α-THP) and 3α,5α- tetrahydrodeoxycorticosterone (3α,5α-THDOC) were shown to modulate neuronal excitability via their interaction with GABA A receptors. The steroids 3α,5α-THP and 3α,5α-THDOC were able to enhance the GABA-elicited Cl − current. [13] In addition, these steroids might enhance the binding of muscimol and benzodiazepines to GABA A receptors. [30] Structure- activity studies (SAR) showed that the 3alpha-OH group is essential for the anesthetic actions of these steroids, [31] they also have an optimally-placed hydrogen bond accepting group on the β face of the steroid at the C-17 position. The four steroid rings form a rigid framework for positioning these hydrogen groups in three-dimensional space. [32] Analogues 5 and 6 (Figure 10) are weak modulators of GABA A receptor function because the flexible side chains in these analogues do not have the conformations required for high biological activity. [33]

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* Daily Multivitamin (NOW Foods – Adam)
* Omega 3 Fish Oil – DHA/EPA (Dr. Tobias Omega 3 Fish Oil Triple Strength) – starting with 300 mg DHA/day
* Vitamin B-Complex (Jarrow B-Right)
* Magnesium Glycinate (Dr’s Best) – 200 mg/day
* Acetyl-l-Carnitine (NOW Foods) – 500 mg/day
* Bacopa Monnieri (Himalaya Organic) – 750 mg/day
* Berberine (We Like Vitamins) 450 mg/day
* CDP Choline (Jarrow) 250 mg/day
* Curcumin w/piperine (NatureWise) 825 mg/day
* Lion’s mane (Relentless) 750 mg/day
* N-Acetyl-l-tyrosine (Jarrow) 350 mg/day
* Phosphatidylserine (Dr’s Best) 100 mg/day
* Pterostilbene (Jarrow) 50 mg/day
* Pine bark extract **not Pycnogenol** (NOW Foods) 240 mg/day
I’ve only started taking the multi vitamin, fish oil, B-complex, magnesium, CDP Choline, and Berberine at the lowest dosages, which are listed. I have a few questions:
* Do I have too much duplication?
* If so, which would you recommend eliminating?
* Are there any nootropics in the list that you would replace with something not listed?
* Are the manufacturers, that I listed, reliable?
I know a lot depends on each individual, but any feedback would be greatly appreciated.

Our proprietary approach to drug discovery and development has generated selective compounds with precise pharmacologic properties that may be applied to the treatment of multiple CNS disorders. These compounds, which we call next-generation neurosteroids, have improved pharmacokinetic properties that may allow for both oral availability and improved therapeutic indexes. As a result, they may be better suited for long-term, or chronic, use. SAGE-689 and SAGE-217 are next-generation neurosteroids we have selected as clinical candidates.

Neurosteroids depression

neurosteroids depression

Our proprietary approach to drug discovery and development has generated selective compounds with precise pharmacologic properties that may be applied to the treatment of multiple CNS disorders. These compounds, which we call next-generation neurosteroids, have improved pharmacokinetic properties that may allow for both oral availability and improved therapeutic indexes. As a result, they may be better suited for long-term, or chronic, use. SAGE-689 and SAGE-217 are next-generation neurosteroids we have selected as clinical candidates.

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