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I have a almost three year old Australian Sheppard/Chow Chow Mix. He has taken Comfortis and Heartgard since I rescued him last November. I decided this month to switch to Trifexis. He received his first dose at breakfast on the 15th of July. I put the pill in with the rest of his food and it is eaten along with the rest of his food during that feeding. I have noticed slighlty more itching but nothing extreme and I have noticed, last night especially, that during his brushing there was quite a lot of hair consumed in the brush. It is shedding season though, so I’m unsure that this is a reaction to the medication. I will continue to monitor my dog and he also has three days a week spent with his personal trainer and some other dogs that do day care as well. Good socializing and excellent time spent with a trainer. As far as Trifexis is concerned, just like any other medication you have to monitor your dog and observe things that are unusual for your dog. Make sure he/she is not getting into other things that could cause bad behavior or mischief that could lead to what appears as adverse reactions to the medicine.
Remember, nothing is alleged to--or can have--happened to all of MLB over some one or two seasons: the claim is that PEDs were being used at a slowly but steadily increasing rate (and thus "distorting records") from very roughly 1980 through the present. Were that so, or anything like it, we would expect to see a clear long-term uptrend during this period. But we don't: we see a nearly flat line that, if anything, slopes slightly down. The "boost" just isn't there. But that doesn't seem to stop anyone from talking about it.