The effects of alcohol intoxication are greatly influenced by individual
variations among users. Some users may become intoxicated at a much
lower Blood Alcohol Concentration (BAC) level than is shown.
- BAC : No loss of coordination, slight euphoria and loss of shyness. Depressant effects are not apparent. Mildly relaxed and maybe a little lightheaded.
- BAC : Feeling of well-being, relaxation, lower inhibitions, sensation of warmth. Euphoria. Some minor impairment of reasoning and memory, lowering of caution. Your behavior may become exaggerated and emotions intensified (Good emotions are better, bad emotions are worse)
- BAC : Slight impairment of balance, speech, vision, reaction time, and hearing. Euphoria. Judgment and self-control are reduced, and caution, reason and memory are impaired, .08 is legally impaired and it is illegal to drive at this level. You will probably believe that you are functioning better than you really are.
- BAC : Significant impairment of motor coordination and loss of good judgment. Speech may be slurred; balance, vision, reaction time and hearing will be impaired. Euphoria.
- BAC : Gross motor impairment and lack of physical control. Blurred vision and major loss of balance. Euphoria is reduced and dysphoria (anxiety, restlessness) is beginning to appear. Judgment and perception are severely impaired.
- BAC : Dysphoria predominates, nausea may appear. The drinker has the appearance of a "sloppy drunk."
BAC : Felling dazed, confused or otherwise disoriented. May need help to stand or walk. If you injure yourself you may not feel the pain. Some people experience nausea and vomiting at this level. The gag reflex is impaired and you can choke if you do vomit. Blackouts are likely at this level so you may not remember what has happened.
BAC : All mental, physical and sensory functions are severely impaired. Increased risk of asphyxiation from choking on vomit and of seriously injuring yourself by falls or other accidents.
BAC : STUPOR. You have little comprehension of where you are. You may pass out suddenly and be difficult to awaken.
BAC: Coma is possible. This is the level of surgical anesthesia.
BAC and up : Onset of coma, and possible death due to
The use of beta-blockers for cocaine cardiovascular toxicity has been subject to a relative contraindication by many clinicians for several years despite extremely limited evidence. The phenomenon of “unopposed alpha-stimulation,” in which blood pressure increases or coronary artery vasoconstriction worsens after blockade of beta-2 vasodilation in cocaine-abusing patients, is controversial.   This rarely-encountered and unpredictable adverse effect has resulted in some clinicians advocating for an absolute contraindication of the use of all beta-blockers, including specific, non-specific, and mixed.  Many clinicians have disregarded this dogma and administer beta-blockers for cocaine-related chest pain and acute coronary syndrome, especially when there is demand ischemia from uncontrolled tachycardia.      Of the 1,744 total patients identified in the aforementioned systematic review,  only 7 adverse events were from putative cases of “unopposed alpha-stimulation” due to propranolol (n=3), esmolol (n=3), and metoprolol (n=1).      Some detractors of beta-blockers for cocaine-induced chest pain have cited minimal acute mortality and the short half-life of the drug, making it unnecessary to aggressively treat any associated tachycardia and hypertension.   However, the long-term effect of cocaine use and development of heart failure, with early mortality, high morbidity, and tremendous demand on hospital utilization should be taken under consideration.   
The Drug and Alcohol Crash Risk report, produced by the Department of Transportation’s National Highway Traffic Safety Administration, found that while drunken driving dramatically increased the risk of getting into an accident, there was no evidence that using marijuana heightened that risk. In fact, after adjusting for age, gender, race and alcohol use, the report found that stoned drivers were no more likely to crash than drivers who were not intoxicated at all.
It’s worth taking a closer look at that 2015 NHTSA study, because federal officials put a lot of stock in it as “the first large-scale [case control crash risk] study in the United States to include drugs other than alcohol.” Data was collected from more than 3,000 crash-involved drivers and 6,000 control drivers (not involved in crashes) over a 20-month period in Virginia Beach, Virginia. The data was fresh and solid: Research teams responded to crashes 24 hours a day, 7 days a week. Drivers were considered THC-positive if they tested for active THC, not for non-impairing metabolites still in their blood days or weeks after consumption.
While THC-positive drivers were 5% more likely to be involved in a crash, the researchers found that drivers who’d taken an opioid painkiller had a 14% greater risk of crashing. Here’s a chart from that NHTSA study comparing THC (marijuana) with opioids (narcotic analgesics) and other drugs:
Those levels of increased risk were tiny, however, compared to the risk involved with alcohol. Drivers within the legal range of blood alcohol level as registered by a breathalyzer (BrAC) were found to be 20% to 222% more likely to be involved in a crash. At .08 BrAC, the legal limit, the risk increased to 293%. At BrAC, drivers were more than 12 times (+1118%) more likely to be involved in a crash than a sober person. Here’s a chart from that same study, calculating the increased risk of crashing at rising blood alcohol levels:
By comparison, a driver who has taken penicillin is 25% more likely to be involved in a crash. Drivers carrying two or more passengers are 120% more likely to crash. Drivers using mobile phones to talk or text are 310% more likely to crash.
A separate NHSTA study (“Marijuana And Actual Driving Performance”) further conceded it’s “difficult to establish a relationship between a person’s THC blood or plasma concentration and performance impairing effects … Drivers with high concentrations showed substantial [impairment], but also no impairment, or even some improvement.” In other words, cannabis affects different drivers in different ways, depending on a number of factors.