Hydrophilic steroid hormones

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When only mg of progesterone was applied topically, the plasma level rose 39 percent, whereas saliva level rose 5-fold. This indicates that only a small portion of the added progesterone entered the plasma, whereas the saliva clearly showed a hefty increase of bioavailable progesterone. When an 88-fold larger dose was applied topically, the plasma level rose only -fold while the simultaneous saliva level rose 57-fold. This indicates that only the saliva reflected the great increase in absorbed bioavailable progesterone. The progesterone found in the saliva obviously was blood-borne, but it should be clear that the portion of the blood carrying the progesterone was not the plasma (serum) but, rather, was via red blood cells.

Hydrophilic steroid hormones

hydrophilic steroid hormones

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