The fetal adrenal cortex lacks expression of the enzyme early on, thus mineralocorticoids (. aldosterone ) and glucocorticoids (. cortisol ) cannot be synthesized. This is significant because cortisol induces type II pneumocytes of the lungs to synthesize and secrete pulmonary surfactant ; without pulmonary surfactant to reduce the alveolar surface tension , premature neonates may die of neonatal respiratory distress syndrome . If delivery is unavoidable (. because of placental abruption , or pre-eclampsia / HELLP syndrome ), then glucocorticoids (. cortisol) can be administered.
Over-inhibition of 5AR results in increased availability of testosterone, which may be shunted, via aromatase, to estradiol, causing “feminization,” ., gynecomastia, one of the side effects of 5AR inhibitor drugs; and decreased production of not only 5α-DHT, but its metabolites, 5α-Androstane-3α-17β-diol ( aka 3α-adiol, a storage form of 5α-DHT), and 5α-Androstane-3β-17β-diol ( aka 3β-adiol), an estrogen receptor beta (ERβ) ligand that promotes normal cellular differentiation, thus lessening risk of benign prostatic hypertrophy and prostate cancer. 22 , 23 , 24
Inhalants are a group of chemicals including solvents, aerosols, adhesives, gases, cleaning agents, food products, anesthetics and volatile nitrites. These legal substances, most of which are found in everyday household products, are not normally thought of as drugs, but have drug-like effects on the user. The most familiar substances are paint and glue. But include nearly 600 common household, workshop and office products that are dangerous when inhaled. Those products include keyboard aerosol cleaners, felt-tip markers, spray paint, air freshener, butane and aerosol cooking sprays.