"For years I had been a "junkie"--addicted to prescription and over the counter drugs. used oral and topical anti-inflammatory corticosteroids for 9 years to suppress my eczema/psoriasis. The steroids' side effect nearly killed me and did nothing to cure my eczema. The side effects caused me to swell-up like a balloon and triggered terrible mood swings from deep depression to nasty outburst our rages. Functioning of vital organs such as my liver, kidneys, lungs and spleen were nearly shut down and I thought I would die." Shirley
Klaus-Dieter Lessnau, MD, FCCP Clinical Associate Professor of Medicine, New York University School of Medicine; Medical Director, Pulmonary Physiology Laboratory; Director of Research in Pulmonary Medicine, Department of Medicine, Section of Pulmonary Medicine, Lenox Hill Hospital
Klaus-Dieter Lessnau, MD, FCCP is a member of the following medical societies: American College of Chest Physicians , American College of Physicians , American Medical Association , American Thoracic Society , Society of Critical Care Medicine
Disclosure: Nothing to disclose.
The most common side effects with Rapamune (seen in more than 1 patient in 10) are pneumonia (infection of the lungs), infections (fungal, viral, bacterial or by Herpes simplex ), urinary tract infection (infection of the structures that carry urine), thrombocytopenia (low blood platelet counts), anaemia (low red blood cell counts), leucopoenia (low white blood cell counts), hypokalaemia (low blood potassium levels), hypophosphataemia (low blood phosphate levels), hyperlipidaemia (including hypercholesterolaemia (high blood cholesterol levels) and hypertriglyceridaemia (high blood levels of triglycerides, a type of fat)), hyperglycaemia (high blood sugar levels), diabetes, headache, tachycardia (rapid heartbeat), lymphocele (fluid collection around the kidney), hypertension (high blood pressure), abdominal pain (stomach ache), diarrhoea, constipation, nausea (feeling sick), rash, acne, arthralgia (joint pain), proteinuria (protein in the urine), menstrual disorders, oedema (swelling), peripheral oedema (swelling of the ankles and feet), pyrexia (fever), pain, impaired wound healing, increased blood lactate dehydrogenase levels (a marker of tissue breakdown), increased blood creatinine levels (a marker of kidney problems) and abnormal liver function test. Because it reduces the activity of the immune system, Rapamune can also increase the risk of developing cancer, especially lymphoma and skin cancer. For the full list of all side effects reported with Rapamune, see the package leaflet.