Transdermal patches can be a very precise time released method of delivering a drug. Cutting a patch in half might affect the dose delivered. The release of the active component from a transdermal delivery system (patch) may be controlled by diffusion through the adhesive which covers the whole patch, by diffusion through a membrane which may only have adhesive on the patch rim or drug release may be controlled by release from a polymer matrix. Cutting a patch might cause rapid dehydration of the base of the medicine and affect the rate of diffusion.
Separate studies compared Mentax® (butenafine) Cream to vehicle applied once daily for 2 weeks in the treatment of tinea corporis and tinea cruris. Patients were treated for 2 weeks and evaluated 4 weeks post-treatment. All subjects with a positive baseline exam (including positive culture and KOH) and who were dispensed medication were included in the “modified intent-to-treat” analysis shown in the table below. Statistical significance (Mentax® (butenafine) vs. vehicle) was achieved for all patient outcome categories at Week 2 (end of treatment) and Week 6 (4 weeks post-treatment).
In vitro , Clotrimazole exhibits fungistatic and fungicidal activity against isolates of Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis , and Candida species including Candida albicans . In general, the in vitro activity of Clotrimazole corresponds to that of tolnaftate and griseofulvin against the mycelia of dermatophytes ( Trichophyton, Microsporum , and Epidermophyton ), and to that of the polyenes (amphotericin B and nystatin) against budding fungi ( Candida ). Using an in vivo (mouse) and an in vitro (mouse kidney homogenate) testing system, Clotrimazole and miconazole were equally effective in preventing the growth of the pseudomycelia and mycelia of Candida albicans .