Adrenal steroid synthesis ppt

Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandrosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.

AB - Ketaconazole, a broad-spectrum, antifungal drug that is administered orally, has been shown to inhibit sterol synthesis in fungi. When gynecomastia developed in some patients taking this drug, we investigated the effects of ketoconazole on steroid synthesis in humans and in isolated adrenal cells from rats. In healthy humans, the cortisol response to adrenocorticotropic hormone was significantly blunted 4 hours after a 400-mg or 600-mg dose. The inhibition persisted for up to 8 hours and was absent by 16 hours. This finding indicated that adrenal androgen response was reduced. Easily achieved therapeutic concentrations of ketoconazole virtually eliminated corticosterone production by isolated adrenal cells from rats. Although ketaconazole at currently used doses has never been documented to cause clinical hypoadrenalism, caution is urged in high- or multiple-dose trials. The drug may prove useful as an agent to block steroid synthesis.

Microbial catabolism of phytosterol side chains yields C-19 steroids, C-22 steroids, and 17-ketosteroids (. precursors to adrenocortical hormones and contraceptives ). [46] [47] [48] [49] The addition and modification of functional groups is key when producing the wide variety of medications available within this chemical classification. These modifications are performed using conventional organic synthesis and/or biotransformation techniques. [50] [51]

i failed my mblex my first time,dont get discouraged or dont make it the end of the world for IT AGAIN! Find out your weakest points you struggled with on the test & make sure your past comfortable with all topics that are discussed on your test guide. Be expecting the wording of the questions to be different dont let them trick you however pay attention & read the questions carefully! dont think you know it just by looking at the answer choices,most importantly TAKE YOUR TIME! your already nervous the last thing you need to do is to rush your test you shouldnt be done in 20 mins make sure your well rested,eat,use peppermint oil for memory

Adrenal steroid synthesis ppt

adrenal steroid synthesis ppt

i failed my mblex my first time,dont get discouraged or dont make it the end of the world for IT AGAIN! Find out your weakest points you struggled with on the test & make sure your past comfortable with all topics that are discussed on your test guide. Be expecting the wording of the questions to be different dont let them trick you however pay attention & read the questions carefully! dont think you know it just by looking at the answer choices,most importantly TAKE YOUR TIME! your already nervous the last thing you need to do is to rush your test you shouldnt be done in 20 mins make sure your well rested,eat,use peppermint oil for memory

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